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Authors Philips CA, Rajesh S, Augustine P, Padsalgi G, Ahamed R
Received 18 October 2018
Accepted for publication 27 December 2018
Published 25 January 2019 Volume 2019:11 Pages 23—34
DOI https://doi.org/10.2147/HMER.S169024
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Amy Norman
Peer reviewer comments 3
Editor who approved publication: Dr Gerry Lake-Bakaar
Abstract: Portosystemic shunt (PS) syndrome
encompasses a spectrum of disease manifestations ranging from asymptomatic
portal hypertension to recurrent and refractory hepatic encephalopathy,
ultimately culminating in progressive hepatic failure in patients of cirrhosis
and associated large PSs. PSs commonly seen in cirrhosis include splenorenal,
gastrorenal, and dilated paraumbilical veins, all of which can present with
recurrent or refractory hepatic encephalopathy. In this exhaustive review, we
describe the anatomy of PSs, elucidate new theories on their pathophysiology,
discuss the clinical implications of PSs in cirrhosis, provide details on
different techniques (classical and novel) of shunt embolization, and explore
all the pertinent current literature on shunt embolization for refractory and
recurrent hepatic encephalopathy, all of which are enumerated with extensive
images and illustrations.
Keywords: portosystemic
shunts, hepatic encephalopathy, cirrhosis, portal hypertension, embolization,
shunt occlusion
摘要视频链接:Portosystemic
shunts