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Authors Zhang Y, Lin S, Chen Y, Yang F, Liu S
Received 24 January 2018
Accepted for publication 11 March 2018
Published 27 April 2018 Volume 2018:11 Pages 2363—2373
DOI https://doi.org/10.2147/OTT.S163570
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Andrew Yee
Peer reviewer comments 2
Editor who approved publication: Prof. Dr. Geoffrey Pietersz
简介:浸润和转移是胃癌复发和死亡的重要原因。通过体外研究发现乳酸脱氢酶 A (LDH-A) 通过上调 ZEB2 促进肠型胃癌细胞浸润和转移。LDH-A 和 ZEB2 密切相关性在 371 例肠型胃癌组织标本中的到证实。生存分析结果显示: LDH-A 和 ZEB2 联合表达患者预后更差。因此,LDH-A 和 ZEB2 的相关性可能为肠型胃癌提供治疗策略。
Keywords: intestinal-type gastric cancer,
LDH-A, ZEB2, epithelial–mesenchymal transition, Warburg effect, glycolysis
摘要视频链接:Lactate dehydrogenase A