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Authors Middelveen MJ, Fesler MC, Stricker RB
Received 22 September 2017
Accepted for publication 29 December 2017
Published 9 February 2018 Volume 2018:11 Pages 71—90
DOI https://doi.org/10.2147/CCID.S152343
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Amy Norman
Peer reviewer comments 4
Editor who approved publication: Dr Jeffrey Weinberg
Abstract: Morgellons disease (MD) is a skin condition characterized by the
presence of multicolored filaments that lie under, are embedded in, or project
from skin. Although the condition may have a longer history, disease matching
the above description was first reported in the US in 2002. Since that time,
the condition that we know as MD has become a polemic topic. Because
individuals afflicted with the disease may have crawling or stinging sensations
and sometimes believe they have an insect or parasite infestation, most medical
practitioners consider MD a purely delusional disorder. Clinical studies
supporting the hypothesis that MD is exclusively delusional in origin have
considerable methodological flaws and often neglect the fact that mental
disorders can result from underlying somatic illness. In contrast, rigorous
experimental investigations show that this skin affliction results from a physiological
response to the presence of an infectious agent. Recent studies from that point
of view show an association between MD and spirochetal infection in humans,
cattle, and dogs. These investigations have determined that the cutaneous
filaments are not implanted textile fibers, but are composed of the cellular
proteins keratin and collagen and result from overproduction of these filaments
in response to spirochetal infection. Further studies of the genetics,
pathogenesis, and treatment of MD are warranted.
Keywords: Morgellons
disease, dermopathy, Lyme disease, Borrelia burgdorferi ,
spirochetes
摘要视频链接:Morgellons disease