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Authors El-Menshawe SF, Ali AA, Rabeh MA, Khalil NM
Received 7 October 2017
Accepted for publication 6 December 2017
Published 9 January 2018 Volume 2018:13 Pages 307—318
DOI https://doi.org/10.2147/IJN.S153429
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Jiang Yang
Peer reviewer comments 2
Editor who approved publication: Dr Thomas J Webster
Purpose: Herbal supplements are currently available as a safer alternative to
manage obesity, which has become a rising problem over the recent years. Many
chemical drugs on the market are designed to prevent or manage obesity but high
cost, low efficacy, and multiple side effects limit its use. Nano lipo-vesicles
phytosomal thermogel of Soybean, Glycine max (L.) Merrill, was formulated and
evaluated in an attempt to investigate its anti-obesity action on body weight
gain, adipose tissue size, and lipid profile data.
Methods: Three different techniques were used to prepare
phytosome formulations including solvent evaporation, cosolvency, and salting
out. The optimized phytosome formulation was then selected using Design Expert® (version 7.0.0) depending on the highest
entrapment efficiency, minimum particle size (PS), and maximum drug release
within 2 hours as responses for further evaluation. The successful phytosome
complex formation was investigated by means of Fourier-transform infrared spectroscopy
and determination of PS and zeta potential. Phytosome vesicles’ shape was
evaluated using transmission electron microscope to ensure its spherical shape.
After characterization of the optimized phytosome formulation, it was
incorporated into a thermogel formulation. The obtained phytosomal thermogel
formulation was evaluated for its clarity, homogeneity, pH, and gel transformation
temperature besides rheology behavior and permeation study. An in vivo study
was done to investigate the anti-weight-gain effect of soy phytosomal thermogel.
Results: EE was found to be >99% for all formulations, PS
ranging from 51.66–650.67 while drug release was found to be (77.61–99.78) in
range. FTIR and TEM results confirmed the formation of phytosome complex. In
vivo study showed a marked reduction in body weight, adipose tissue weight and
lipid profile.
Conclusion: Concisely, soy phytosomal thermogel was found to have
a local anti-obesity effect on the abdomen of experimental male albino rats
with a slight systemic effect on the lipid profile data.
Keywords: soy, Glycine max , lipase, phytosomal
thermogel, topical delivery, natural treatment
摘要视频链接:Soy phytosome-based thermogel
as topical anti-obesity formulation