Background: Obese people have a higher prevalence of cardiovascular disease, which is supposed to be due to autonomic dysfunction and/or metabolic disorder. The alterations in cardiac autonomic functions bring out the changes in the heart rate variability (HRV) indicators, an assessing tool for cardiac autonomic conditions.
Objective: To compare the cardiac autonomic activity between obese and normal weight adults and find out the highest association between the indices of HRV and obesity.
Methods: The study was conducted in 30 adult obese persons (body mass index [BMI] >30 kg/m²) and 29 healthy normal weight controls (BMI 18–24 kg/m²). Short-term HRV variables were assessed using standard protocol. Data were compared between groups using Mann–Whitney U  test. Obesity indices such as waist circumference, hip circumference, waist–hip ratio (WHR), and BMI were measured and calculated, and they were correlated with HRV indices using Spearman’s correlation analysis.
Results: In the obese group, there was a significant increase in the mean heart rate, whereas the HRV parasympathetic indicators were less (eg, root mean square of differences of successive RR intervals [28.75 {16.72–38.35} vs 41.55 {30.6–56.75} ms, p =0.018], number of RR intervals that differ by >50 ms, that is, NN50 [15.5 {2–39} vs 83.5 {32.75–116.25}, p =0.010], etc) and the sympathetic indicator low frequency (LF)/high frequency (HF) ratio (1.2 [0.65–2.20] vs 0.79 [0.5–1.02], p =0.045) was more than that of the normal weight group. Spearman’s correlation between HRV and obesity indices showed significant positive correlation of WHR with LF in normalized unit (r =0.478, p <0.01) and LF/HF ratio (r =0.479, p <0.01), whereas it had significant negative correlation with high frequency power ms² (r =−0.374, p <0.05) and HF in normalized unit (r =−0.478, p <0.01). There was a nonsignificant correlation of BMI with HRV variables in obese individuals.
Conclusion: Increased WHR, by far an indicator of visceral adiposity, was strongly associated with reduced cardiac parasympathetic and increased sympathetic activity in obese individuals defined by BMI. However, BMI itself has a weak relationship with HRV cardiac autonomic markers. Thus, even with a slight increase in WHR in an individual, there could be a greater risk of cardiovascular morbidity and mortality brought about by cardiac autonomic alterations.
Keywords: obesity, heart rate variability, HRV, body mass index, BMI, waist–hip ratio, WHR, cardiac autonomic regulation

摘要视频链接：Association between obesity and HRV indices