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已发表论文
与前列腺癌风险有关的膳食纤维、全谷类、糖类、血糖指数和血糖负荷
Authors Wang RJ, Tang JE, Chen Y, Gao JG
Received 13 May 2015
Accepted for publication 30 July 2015
Published 2 September 2015 Volume 2015:8 Pages 2415—2426
DOI http://dx.doi.org/10.2147/OTT.S88528
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Narasimha Reddy Parine
Peer reviewer comments 3
Editor who approved publication: Dr Faris Farassati
Background: The relationships between dietary fiber, whole grains, carbohydrate, glycemic index (GI), glycemic load (GL), and prostate cancer risk are unclear. We conducted a systematic review and meta-analysis to investigate these associations.
Methods: Relevant studies were identified by a search of PubMed database and EMBASE database up to April 2015. A random effects model was used to calculate the summary relative risks (RRs) and their corresponding 95% confidence intervals (CIs).
Results: Twenty-seven epidemiological studies (18 case–control studies and nine cohort studies) were included in the final analysis. The pooled RRs of prostate cancer were 0.94 (95% CI 0.85–1.05, P =0.285), 1.13 (95% CI 0.98–1.30, P =0.095), 0.96 (95% CI 0.81–1.14, P =0.672), 1.06 (95% CI 0.96–1.18, P =0.254), and 1.04 (95% CI 0.91–1.18, P =0.590) for dietary fiber, whole grains, carbohydrate, GI, and GL, respectively. There was no evidence of significant publication bias based on the Begg’s test and Egger’s test.
Conclusion: The findings of this meta-analysis indicate that, based on available information, dietary fiber, whole grains, carbohydrate, GI, and GL are not associated with the risk of prostate cancer.
Keywords: prostate cancer, fiber, whole grains, carbohydrate, glycemic index, glycemic load
Methods: Relevant studies were identified by a search of PubMed database and EMBASE database up to April 2015. A random effects model was used to calculate the summary relative risks (RRs) and their corresponding 95% confidence intervals (CIs).
Results: Twenty-seven epidemiological studies (18 case–control studies and nine cohort studies) were included in the final analysis. The pooled RRs of prostate cancer were 0.94 (95% CI 0.85–1.05, P =0.285), 1.13 (95% CI 0.98–1.30, P =0.095), 0.96 (95% CI 0.81–1.14, P =0.672), 1.06 (95% CI 0.96–1.18, P =0.254), and 1.04 (95% CI 0.91–1.18, P =0.590) for dietary fiber, whole grains, carbohydrate, GI, and GL, respectively. There was no evidence of significant publication bias based on the Begg’s test and Egger’s test.
Conclusion: The findings of this meta-analysis indicate that, based on available information, dietary fiber, whole grains, carbohydrate, GI, and GL are not associated with the risk of prostate cancer.
Keywords: prostate cancer, fiber, whole grains, carbohydrate, glycemic index, glycemic load
