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已发表论文
胃促胰酶在瘢痕局部组织的肾素 - 血管紧张素系统中的作用： 抑制胃促胰酶可能是瘢痕疙瘩的一种有效治疗方法
Authors Wang R, Chen J, Zhang Z, Cen Y
Received 3 May 2015
Accepted for publication 22 May 2015
Published 28 August 2015 Volume 2015:9 Pages 4979—4988
DOI http://dx.doi.org/10.2147/DDDT.S87842
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Arun Kapoor
Peer reviewer comments 3
Editor who approved publication: Professor Wei Duan
Background: Histologically, keloids contain excess fibroblasts and an overabundance of dermal collagen. Recently, it was reported that chymase induced a profibrotic response via transforming growth factor-β1 (TGF-β1)/Smad activation in keloid fibroblasts (KFs). However, the role of chymase in the local renin-angiotensin system (RAS) in keloids has not been elucidated. This study aims to determine whether chymase plays an important role in the local RAS in keloids.
Methods: We compared the expression and activity of chymase in keloids and normal skin tissues using Western blotting and radioimmunoassay, and studied the expression of TGF-β1, interleukin-1β, collagen I, hydroxyproline, and angiotensin II in KFs after chymase and inhibitors’ treatment.
Results: The results revealed an increased activity of chymase in keloid tissues, and that chymase enhanced the expression of angiotensin II, collagen I, TGF-β1, and interleukin-1β in KFs. Blockade of the chymase pathway involved in the local RAS lowered the expression of these signaling factors.
Conclusion: This research suggests that inhibition of chymase might be an effective therapeutic approach to improve the clinical treatment of keloids.
Keywords: pathological scar, chymase, angiotensin II, therapy
Methods: We compared the expression and activity of chymase in keloids and normal skin tissues using Western blotting and radioimmunoassay, and studied the expression of TGF-β1, interleukin-1β, collagen I, hydroxyproline, and angiotensin II in KFs after chymase and inhibitors’ treatment.
Results: The results revealed an increased activity of chymase in keloid tissues, and that chymase enhanced the expression of angiotensin II, collagen I, TGF-β1, and interleukin-1β in KFs. Blockade of the chymase pathway involved in the local RAS lowered the expression of these signaling factors.
Conclusion: This research suggests that inhibition of chymase might be an effective therapeutic approach to improve the clinical treatment of keloids.
Keywords: pathological scar, chymase, angiotensin II, therapy
