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已发表论文
在采用贝伐珠单抗 (Bevacizumab) 治疗的非小细胞肺癌 (NSCLC) 患者中高血压的发病率和风险 ：对随机对照试验的一项综合分析
Authors Chen J, Lu Y, Zheng Y
Received 24 April 2015
Accepted for publication 7 July 2015
Published 18 August 2015 Volume 2015:9 Pages 4751—4760
DOI http://dx.doi.org/10.2147/DDDT.S87258
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Syed Nasir Abbas Bhukari
Peer reviewer comments 3
Editor who approved publication: Professor Shu-Feng Zhou
Aim: A study was conducted to determine the overall risk and incidence of hypertension with bevacizumab in non-small-cell lung cancer (NSCLC) patients.
Materials and methods: Electronic databases such as the Embase, PubMed, and Cochrane Library were searched for related trials. Statistical analyses were conducted to calculate the overall incidence rates, odds ratios (ORs), and 95% confidence intervals (CIs) by using either random-effect or fixed-effect models depending on the heterogeneity.
Results: A total of 3,155 subjects from nine studies were included. The overall incidences of all-grade and high-grade hypertension in NSCLC patients were 19.55% (95% CI 10.17%–34.3%) and 6.95% (95% CI 5.81%–8.30%). Bevacizumab use was associated with a significantly increased risk in all-grade hypertension (OR 8.07, 95% CI 3.87–16.85; P =0.0002) and high-grade hypertension (OR 5.93, 95% CI 3.41–10.32; P <0.0001). No evidence of publication bias was determined for the ORs of hypertension in our meta-analysis.
Conclusion: Bevacizumab is associated with a significantly increased risk of hypertension development in NSCLC patients. Early monitoring and effective management of hypertension might be important steps for the safe use of this drug.
Keywords: non-small-cell lung cancer, bevacizumab, hypertension, meta-analysis
Materials and methods: Electronic databases such as the Embase, PubMed, and Cochrane Library were searched for related trials. Statistical analyses were conducted to calculate the overall incidence rates, odds ratios (ORs), and 95% confidence intervals (CIs) by using either random-effect or fixed-effect models depending on the heterogeneity.
Results: A total of 3,155 subjects from nine studies were included. The overall incidences of all-grade and high-grade hypertension in NSCLC patients were 19.55% (95% CI 10.17%–34.3%) and 6.95% (95% CI 5.81%–8.30%). Bevacizumab use was associated with a significantly increased risk in all-grade hypertension (OR 8.07, 95% CI 3.87–16.85; P =0.0002) and high-grade hypertension (OR 5.93, 95% CI 3.41–10.32; P <0.0001). No evidence of publication bias was determined for the ORs of hypertension in our meta-analysis.
Conclusion: Bevacizumab is associated with a significantly increased risk of hypertension development in NSCLC patients. Early monitoring and effective management of hypertension might be important steps for the safe use of this drug.
Keywords: non-small-cell lung cancer, bevacizumab, hypertension, meta-analysis
