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磷脂酰乙醇胺结合蛋白4在肿瘤中的作用及信号转导途径
Authors Luo ZK, Chen QF, Qu X, Zhou XY
Received 17 May 2019
Accepted for publication 9 September 2019
Published 18 September 2019 Volume 2019:12 Pages 7685—7690
DOI https://doi.org/10.2147/OTT.S216161
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Ms Aruna Narula
Peer reviewer comments 2
Editor who approved publication: Prof. Dr. Geoffrey Pietersz
摘要：磷脂酰乙醇胺结合蛋白 4（PEBP4）在多种肿瘤中高表达，并且与肿瘤的增殖、分化和转移密切相关。PEBP4 被发现参与了许多癌症激活的信号通路。本文首先介绍了 PEBP4 的结构和表达情况。然后，探讨了 PEBP4 在肿瘤治疗中的作用，以及成为新的治疗靶点的可能性。最后，介绍了 PEBP4 调节癌症的主要信号途径。总之，PEBP4 的过度表达可以促进肿瘤细胞增殖和转移，增强肿瘤对放化疗的抵抗力。
关键词：PEBP4；信号通路；靶向治疗
