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来自中国的 bla KPC 和 bla NDM 共同生产的肺炎克雷伯菌菌株的耐药基因和毒力基因的多样性和频率
Authors Liu X, Zhang J, Li Y, Shen Q, Jiang W, Zhao K, He Y, Dai P, Nie Z, Xu X, Zhou Y
Received 8 May 2019
Accepted for publication 26 July 2019
Published 10 September 2019 Volume 2019:12 Pages 2819—2826
DOI https://doi.org/10.2147/IDR.S214960
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Amy Norman
Peer reviewer comments 2
Editor who approved publication: Dr Joachim Wink
Background: Emergence of bla KPC and bla NDM co-producing Klebsiella pneumoniae strains have led to the limited therapeutic options for clinical treatment. Understanding the diversity and frequency of resistance and virulence genes of these isolates is of great significance.
Purpose: The aim of this study is to research the diversity and frequency of resistance and virulence genes in the bla KPC and bla NDM co-producing Klebsiella pneumoniae strains.
Methods and Results: In this study, 117 K. pneumonia strains were isolated from China, and among of which, 24 were found to be bla KPC and bla NDM co-producing with significant resistance against almost all the commonly used antibiotics. Additionally, 4 strains were hypermucoviscous and 8 showed high serum resistance. Overall, bla SHV, bla CTX-M, tetA and sul1 resistance genes found in 100% of the isolates, followed by bla TEM (95.8%), oqxA/B (91.7%), qnrB (87.5%), aac(6’)Ib-cr (83.3%), bla DHA (79.2%), rmtB (66.7%), qnrS (54.2%), cat (54.2%), floR (50.0%), sul2 (45.8%)
cmlA (20.8%) and bla CMY (8.33%), respectively. What’ more, seven bla CTX-M subtypes [bla CTX-M-14 (n=18), bla CTX-M-3 (n=11), bla CTX-M-65 (n=4), bla CTX-M-15 (n=3), bla CTX-M-28 (n=2), bla CTX-M-55 (n=2), bla CTX-M-22 (n=1)] and six bla SHV subtypes [bla SHV-12 (n=16), bla SHV-11 (n=4), bla SHV-2a (n=1), bla SHV-1 (n=1), bla SHV-38 (n=1) and bla SHV-28 (n=1)] were detected. The frequency of virulence genes was as follows: 100% for entB , ybtS and irp , 95.8% for mrkD , 91.66% for fimH , 79.2% for iutA , 62.5% for iroBCDE , aerobactin and kfu , 66.7% for allS , 45.8% for wcaG, 37.5% for rmpA , 20.8% for pagO and 16.7% for magA .
Conclusion: From this study, we concluded that the bla KPC and bla NDM co-producing Klebsiella pneumoniae strains have a high diversity and frequency of resistance and virulence genes. This study may offer hospitals important information about the control of infections caused by bla KPC and bla NDM co-producing Klebsiella pneumoniae .
Keywords: Klebsiella pneumoniae , bla NDM, bla KPC, resistance genes, virulence factors
