Abstract: Acute myeloid leukemia (AML) originates from the abnormal clonal proliferation of myeloblasts. Immunoglobulin is secreted by B cells. AML with monoclonal antibody often indicates a poor prognosis. Here we report a case of BCOR  mutation and TLS-ERG  expression in AML with monoclonal immunoglobulinemia. After chemotherapy, the patient achieved bone marrow complete remission. BCOR  mutation and TLS-ERG  fusion gene in patient’s bone marrow were not detected, at the same time, peripheral blood monoclonal immunoglobulin also disappeared. BCOR  mutation or TLS-ERG  fusion gene expression is associated with poor prognosis, AML with monoclonal immunoglobulin may have the same prognostic significance.
Keywords: acute myeloid leukemia, bone marrow, monoclonal immunoglobulin, TLS-ERG, BCOR