已发表论文

通过白蛋白剥离制备的二硫化钛纳米片:用于光热/放射协同疗法治疗结肠癌的多功能纳米平台

 

Authors Cao C, Zhang J, Yang C, Xiang L, Liu W

Received 30 March 2019

Accepted for publication 21 June 2019

Published 9 August 2019 Volume 2019:12 Pages 6337—6347

DOI https://doi.org/10.2147/OTT.S210618

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Ms Aruna Narula

Peer reviewer comments 2

Editor who approved publication: Dr Takuya Aoki

Purpose: TiS2-HSA-FA, a nanoagent based on titanium disulfide (TiS2), human serum albumin (HSA), and folic acid (FA), was synthesized for potential use in synergistic photothermal/radiation therapy for colon cancer.
Methods: TiS2 nanosheets were synthesized through a HSA-assisted exfoliation method and then modified with PEGylated FA. The morphology, size, zeta potential, stability, cellular uptake, cytotoxicity, biodistribution, and in vitro and in vivo biocompatibility of the nanoparticles as well as their suitability for synergistic photothermal/radiation colon cancer therapy were investigated.
Results: The as-synthesized TiS2-HSA-FA nanoparticles showed excellent physiological stability, as well as high absorption values in the near-infrared (NIR) and X-ray regions, giving them superb activity as a photothermal and radiation sensitizer. In vitro and in vivo experiments indicated that TiS2-HSA-FA showed high tumor targeting selectivity, blood circulation time, biocompatibility, and suitability for synergistic tumor photothermal radiotherapy.
Conclusion: A multifunctional nanoplatform based on TiS2 was developed and found to be potentially suitable for synergistic photothermal/radiation therapy for colon cancer.
Keywords: titanium disulfide, tumor target, photothermal therapy, radiotherapy, synergistic colon cancer therapy




Figure 4 In vitro photothermal radiotherapy.