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已发表论文
共轭的树枝状聚合物及超声波介导的透皮双氯芬酸 (Diclofenac) 药物输送系统
Authors Huang B, Dong WJ, Yang GY, Wang W, Ji CH, Zhou FN
Published Date July 2015 Volume 2015:9 Pages 3867—3876
DOI http://dx.doi.org/10.2147/DDDT.S75702
Received 11 October 2014, Accepted 1 December 2014, Published 23 July 2015
Abstract: The purpose of the present study was to develop a novel transdermal
drug-delivery system comprising a polyamidoamine dendrimer coupled with
sonophoresis to enhance the permeation of diclofenac (DF) through the skin. The
novel transdermal drug-delivery system was developed by using a statistical
Plackett–Burman design. Hairless male Wistar rat skin was used for the
DF-permeation study. Coupling media concentration, ultrasound-application time,
duty cycle, distance from probe to skin, and a third-generation polyamidoamine-dendrimer
concentration were selected as independent variables, while in vitro drug
release was selected as a dependent variable. Independent variables were found
to be statistically significant (P <0.05). DF
gel without dendrimer and ultrasound treatment to skin (passive delivery, run
13) showed 56.69 µg/cm2 cumulative drug permeated through the skin,
while the DF-dendrimer gel without sonophoresis treatment (run 14) showed 257.3
µg/cm2 cumulative drug permeated through the skin after 24 hours.
However, when the same gel was applied to sonophoresis-treated skin, drastic
permeation enhancement was observed. In the case of run 3, the cumulative drug
that permeated through the skin was 935.21 µg/cm2. It was concluded
that dendrimer-coupled sonophoresis-mediated transdermal drug delivery system
has the potential to enhance the permeation of DF through the skin.
Keywords: sonophoresis, ultrasound, polyamidoamine, permeation enhancers, stratum corneum
Keywords: sonophoresis, ultrasound, polyamidoamine, permeation enhancers, stratum corneum
