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pH，GSH，H2O2 或 H2S 响应的智能纳米药物用于癌症诊疗
Authors Li Y, An L, Lin J, Tian Q, Yang S
Received 26 March 2019
Accepted for publication 23 May 2019
Published 24 July 2019 Volume 2019:14 Pages 5729—5749
DOI https://doi.org/10.2147/IJN.S210116
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Thiruganesh Ramasamy
Peer reviewer comments 2
Editor who approved publication: Dr Linlin Sun
摘要：肿瘤精准诊断和治疗一直是一个非常重要且具有挑战性的难题。近年来，尽管纳米诊疗药物在肿瘤诊断和治疗方面已经展现出巨大的潜力，但是其在全身中的非特异性靶向分布依旧导致低诊断信噪比和潜在的全身毒副作用。最近，利用肿瘤微环境（TME）激活智能纳米药物的诊断和治疗功能被认为是一种能够有效提高诊断和治疗的灵敏度、选择性、同时有效降低毒副作用的策略。本文将介绍和总结近年来肿瘤微环境响应的智能纳米药物的研究进展，重点介绍智能纳米药物的设计、构建及其在肿瘤诊断和治疗应用。
Keywords: tumor microenvironment, smart nanomedicine agents, theranostic agents, smart nanoprobes, smart nanocarriers
