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一例在慢性粒细胞白血病中发生的原发性胃弥漫性大 B 细胞淋巴瘤
Authors Cai Z, Liu S, Zi J, Ma J, Ge Z
Received 19 April 2019
Accepted for publication 19 June 2019
Published 22 July 2019 Volume 2019:12 Pages 5917—5923
DOI https://doi.org/10.2147/OTT.S212838
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Shashank Kaushik (PT)
Peer reviewer comments 2
Editor who approved publication: Dr Sanjeev Srivastava
Abstract: Chronic myeloid leukemia (CML) and Non-Hodgkin Lymphoma (NHL) are two different origins of hematological malignancies, which rarely occur at the same time. Moreover, NHL secondary to CML is common in T cell lymphoma, while NHL of B cell origin is rare. Since 1999, only 22 cases with B cell lymphoma have been reported, of which 4 cases have diffuse large B-cell lymphoma (DLBCL). The lesions of DLBCL were in lymph node, liver, jejunum, and soft palate. To our knowledge, it has no report for the primary gastric DLBCL (PG-DLBCL) occurring in CML. Here we reported a 63-year-old man of chronic phase (CP) CML associated with PG-DLBCL. The patient was diagnosed with CML nearly eight years ago and was treated with imatinib and nilotinib successively. However, gastroscopy found malignant lesions in the patient’s stomach in March 2018, and the masses were diagnosed as PG-DLBCL. Subsequently, with the treatment of the RCOP + lenalidomide regimen chemotherapy for 3 cycles, the patient achieved nearly complete remission (CR).
Keywords: primary gastric diffuse large B-cell lymphoma, chronic myeloid leukemia, simultaneous