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已发表论文
FH535 抑制胰腺癌细胞的转移和生长
Authors Wu MY, Liang RR, Chen K, Shen M, Tian YL, Li DM, Duan WM, Gui Q, Gong FR, Lian L, Li W, Tao M
Published Date July 2015 Volume 2015:8 Pages 1651—1670
DOI http://dx.doi.org/10.2147/OTT.S82718
Received 12 February 2015, Accepted 11 May 2015, Published 6 July 2015
Approved for publication by Professor Jianmin Xu
Abstract: FH535 is a small-molecule inhibitor of the Wnt/β-catenin signaling pathway, which a substantial body of evidence has proven is activated in various cancers, including pancreatic cancer. Activation of the Wnt/β-catenin pathway plays an important role in tumor progression and metastasis. We investigated the inhibitory effect of FH535 on the metastasis and growth of pancreatic cancer cells. Western blotting and luciferase reporter gene assay indicated that FH535 markedly inhibited Wnt/β-catenin pathway viability in pancreatic cancer cells. In vitro wound healing, invasion, and adhesion assays revealed that FH535 significantly inhibited pancreatic cancer cell metastasis. We also observed the inhibitory effect of FH535 on pancreatic cancer cell growth via the tetrazolium and plate clone formation assays. Microarray analyses suggested that changes in the expression of multiple genes could be involved in the anti-cancer effect of FH535 on pancreatic cancer cells. Our results indicate for the first time that FH535 inhibits pancreatic cancer cell metastasis and growth, providing new insight into therapy of pancreatic cancer.
Keywords: pancreatic cancer, FH535, β-catenin, metastasis, growth
Keywords: pancreatic cancer, FH535, β-catenin, metastasis, growth
