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含锂的介孔生物玻璃和 mPEG-PLGA-b -PLL 共聚物组成的生物复合支架的降解性、生物活性以及骨生成

 

Authors Cai Y, Guo L, Shen H, An X, Jian H, Ji F, Niu Y

Published Date June 2015 Volume 2015:10 Pages 4125—4136

DOI http://dx.doi.org/10.2147/IJN.S82945

Received 15 February 2015, Accepted 6 April 2015, Published 24 June 2015

Approved for publication by Dr Lei Yang

Abstract: Biocomposite scaffolds of lithium (Li)-containing mesoporous bioglass and monomethoxy poly(ethylene glycol)-poly(D,L-lactide-co-glycolide)-poly(L-lysine) (mPEG-PLGA-b -PLL) copolymer were fabricated in this study. The results showed that the water absorption and degradability of Li-containing mesoporous bioglass/mPEG-PLGA-b -PLL composite (l-MBPC) scaffolds were obviously higher than Li-containing bioglass/mPEG-PLGA-b -PLL composite (l-BPC) scaffolds. Moreover, the apatite-formation ability of l-MBPC scaffolds was markedly enhanced as compared with l-BPC scaffolds, indicating that l-MBPC scaffolds containing mesoporous bioglass exhibited good bioactivity. The cell experimental results showed that cell attachment, proliferation, and alkaline phosphatase activity of MC3T3-E1 cells on l-MBPC scaffolds were remarkably improved as compared to l-BPC scaffolds. In animal experiments, the histological elevation results revealed that l-MBPC scaffolds significantly promoted new bone formation, indicating good osteogenesis. l-MBPC scaffolds with improved properties would be an excellent candidate for bone tissue repair.
Keywords: MBG, copolymer, degradability, bioactivity, osteogenesis, cell proliferation, bone repair






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