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VH 和 rhBMP-2 从纳米多孔镁-锌-硅干凝胶中缓释出来，用于骨髓炎治疗和骨修复

 

Authors Li FQ, Wu W, Xiang L, Weng G, Hong H, Jiang H, Qian J

Published Date June 2015 Volume 2015:10 Pages 4071—4080

DOI http://dx.doi.org/10.2147/IJN.S82486

Received 9 February 2015, Accepted 28 March 2015, Published 22 June 2015

Approved for publication by Dr Lei Yang

Abstract: Nanoporous magnesium–zinc–silicon (n-MZS) xerogels with a pore size of ~4 nm, a surface area of 718 cm2/g, and a pore volume of 1.24 cm3/g were synthesized by a sol–gel method. The n-MZS xerogels had high capacity to load vancomycin hydrochloride (VH) and human bone morphogenetic protein-2 (rhBMP-2), after soaking in phosphate buffered saline (PBS) for 24 hours (1.5 and 0.8 mg/g, respectively). Moreover, the n-MZS xerogels exhibited the sustained release of VH and rhBMP-2 as compared with magnesium–zinc–silicon (MZS) xerogels without nanopores (showing a burst release). The VH/rhBMP-2/n-MZS system not only exhibited a good antibacterial property but also promoted the MG63 cell proliferation and differentiation demonstrating good bactericidal activity and cytocompatibility. The results suggested that n-MZS with larger surface area and high pore volume might be a promising carrier for loading and sustained release of VH and rhBMP-2. Hence, the VH/rhBMP-2/n-MZS system might be one of the promising biomaterials for osteomyelitis treatment and bone repair.
Keywords: nanoporous xerogels, sustained release, drugs, osteomyelitis, bone regeneration, bactericidal activity, cytocompatibility






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