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miRNA 参与吗啡耐受的研究进展
Authors Huang J, Wang J, Guo Q, Zou W
Received 14 September 2018
Accepted for publication 25 March 2019
Published 10 April 2019 Volume 2019:12 Pages 1139—1147
DOI https://doi.org/10.2147/JPR.S187592
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Amy Norman
Peer reviewer comments 4
Editor who approved publication: Dr Erica Wegrzyn
摘要：吗啡常用于临床中、重度疼痛的治疗中，然而，长期或反复的吗啡应用将导致吗啡耐受。吗啡耐受致临床疼痛治疗越加困难，限制了吗啡的临床镇痛应用。目前吗啡耐受的分子机制尚未完全清楚，miRNA 是一类含有 18-22 个核苷酸的短链非编码 RNA，通过转录后调控相应靶基因的表达，参与多种疾病的病理生理机制。miRNA 与靶基因 mRNA 的 3’-UTR（非编码区）结合，降解转录物或抑制翻译。吗啡耐受导致 miRNA 的上调或下调。本综述就 miRNA 参与吗啡耐受形成的相关分子机制进行阐述。
Keywords: microRNA, morphine tolerance, MOR, β-arrestin 2,
CaMKII/NMDAR
