已发表论文

通过网络药理学系统阐明香叶醇的机理

 

Authors Zhang YF, Huang Y, Ni YH, Xu ZM

Received 28 September 2018

Accepted for publication 16 February 2019

Published 4 April 2019 Volume 2019:13 Pages 1069—1075

DOI https://doi.org/10.2147/DDDT.S189088

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Palas Chanda

Peer reviewer comments 2

Editor who approved publication: Prof. Dr. Cristiana Tanase

摘要本研究采用网络药理学对香叶醇进行系统概述,包括中药系统药理数据库和分析平台Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform,TCMSP评估香叶醇的成药性,比较毒物遗传学数据库The Comparative Toxicogenomics Database,CTD鉴定香叶醇的潜在靶标,基因本体论Gene Ontology,GO和京都百科全书基因和基因组Kyoto Encyclopedia of Genes and Genomes,KEGG分析对上述潜在靶标进行二次分析,最终构建了香叶醇的药物-靶标-信号通路网络图,为后续的实验研究方向提供参考。网络药理学结果提示,香叶醇的理化性质适合成药,并鉴定出 38 个潜在的靶基因,GO 和 KEGG 分析显示这些靶标与炎症免疫反应、癌症和其他生理过程有关,有继续研究的价值。
Keywords: geraniol, druggability, target prediction, enrichment analysis, network pharmacology




Figure 3 GO map of putative target genes. (A) Biological process categories...