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IL-27 rs153109 多态性会增加中国汉族人群患结直肠癌的风险

 

Authors Lyu SX, Ye LC, Wang OC, Huang GL, Yang F, Liu YH, Dong SY

Published Date June 2015 Volume 2015:8 Pages 1493—1497

DOI http://dx.doi.org/10.2147/OTT.S80255

Received 3 January 2015, Accepted 29 April 2015, Published 16 June 2015

Approved for publication by Professor Jianmin Xu

Abstract: IL-27, a new member of the IL-12 family, has been found to have antitumor effects in colorectal cancer (CRC); therefore, polymorphisms of this protein may modulate CRC carcinogenesis. So, we studied the association of single nucleotide polymorphisms of the IL-27  gene with the risk of CRC occurrence using a case–control using 600 CRC patients and matched healthy controls. The IL-27 rs153109 polymorphism was analyzed with polymerase chain reaction-restriction fragment length polymorphism and DNA sequencing methods. Data indicate that GG, GA, and combined A-variant genotypes (GG + GA) conferred significantly greater risk of CRC (P =0.034, 0.002, and 0.001, respectively), and that G alleles were associated with higher susceptibility to CRC (P =0.001). However, no correlation was found between the IL-27 rs153109 polymorphism and particular clinical features. In conclusion, our data demonstrated a clear association of IL-27 rs153109 polymorphism and the risk of CRC development.
Keywords: IL-27, polymorphism, CRC






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