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介孔生物活性玻璃表面改性的聚乳酸-乙醇酸嵌段共聚物静电纤维支架用于骨骼再生

 

Authors Chen SJ, Jian ZY, Huang LS, Xu W, Liu SH, Song DJ, Wan ZM, Vaughn A, Zhan RS, Zhang CY, Wu S, Hu MH, Li JS

Published Date June 2015 Volume 2015:10 Pages 3815—3827

DOI http://dx.doi.org/10.2147/IJN.S82543

Received 10 February 2015, Accepted 6 April 2015, Published 2 June 2015

Approved for publication by Dr Lei Yang

Abstract: A mesoporous bioactive glass (MBG) surface modified with poly(lactic-co-glycolic acid) (PLGA) electrospun fibrous scaffold for bone regeneration was prepared by dip-coating a PLGA electrospun fibrous scaffold into MBG precursor solution. Different surface structures and properties were acquired by different coating times. Surface morphology, chemical composition, microstructure, pore size distribution, and hydrophilicity of the PLGA-MBG scaffold were characterized. Results of scanning electron microscopy indicated that MBG surface coating made the scaffold rougher with the increase of MBG content. Scaffolds after MBG modification possessed mesoporous architecture on the surface. The measurements of the water contact angles suggested that the incorporation of MBG into the PLGA scaffold improved the surface hydrophilicity. An energy dispersive spectrometer evidenced that calcium-deficient carbonated hydroxyapatite formed on the PLGA-MBG scaffolds after a 7-day immersion in simulated body fluid. In vitro studies showed that the incorporation of MBG favored cell proliferation and osteogenic differentiation of human mesenchymal stem cells on the PLGA scaffolds. Moreover, the MBG surface-modified PLGA (PLGA-MBG) scaffolds were shown to be capable of providing the improved adsorption/release behaviors of bone morphogenetic protein-2 (BMP-2). It is very significant that PLGA-MBG scaffolds could be effective for BMP-2 delivery and bone regeneration.
Keywords: mesoporous, scaffolds, bone regeneration, stem cells, BMP-2






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