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已发表论文
贝伐单抗 (Bevacizumab) 与顺铂 (cisplatin) 和螺旋断层放疗相结合治疗局部晚期鼻咽癌
Authors Li JX, Zhao ZF, Wu X, Yao J, Ma L, Ye R, Niu BL, Liang LQ, Zhao X, Wang QQ
Published Date June 2015 Volume 2015:8 Pages 1315—1319
DOI http://dx.doi.org/10.2147/OTT.S80159
Received 1 January 2015, Accepted 10 March 2015, Published 2 June 2015
Approved for publication by Dr William C Cho
Background: In recent years, chemotherapy, radiotherapy, and targeted drugs have been respectively used in nasopharyngeal carcinoma. In our research, we combined all of them for better curative effects.
Materials and methods: Thirty patients with histologically confirmed stage III~IV (without distant metastasis) nasopharyngeal carcinoma were recruited between December 2013 and October 2014 with strict eligibility requirements and exclusion criteria. Bevacizumab 5 mg/kg, 80 mg/m2 cisplatin and 67.5 Gy radiotherapy (helical tomotherapy [TOMO]) was given according to standard treatment protocols.
Results: After 3 months, 24 complete responses (80%) and six partial responses (40%) were observed in our research. Twenty-four patients (80%) experienced oropharyngeal mucositis, 26% patients experienced weight loss caused by pharyngeal pain and dysphagia caused by oropharyngeal mucositis.
Conclusion: Bevacizumab plus cisplatin and TOMO in treatment of locally advanced nasopharyngeal carcinoma can increase curative effects with low side effects and toxicities.
Keywords: bevacizumab, cisplatin, helical tomotherapy (TOMO), nasopharyngeal carcinoma
Materials and methods: Thirty patients with histologically confirmed stage III~IV (without distant metastasis) nasopharyngeal carcinoma were recruited between December 2013 and October 2014 with strict eligibility requirements and exclusion criteria. Bevacizumab 5 mg/kg, 80 mg/m2 cisplatin and 67.5 Gy radiotherapy (helical tomotherapy [TOMO]) was given according to standard treatment protocols.
Results: After 3 months, 24 complete responses (80%) and six partial responses (40%) were observed in our research. Twenty-four patients (80%) experienced oropharyngeal mucositis, 26% patients experienced weight loss caused by pharyngeal pain and dysphagia caused by oropharyngeal mucositis.
Conclusion: Bevacizumab plus cisplatin and TOMO in treatment of locally advanced nasopharyngeal carcinoma can increase curative effects with low side effects and toxicities.
Keywords: bevacizumab, cisplatin, helical tomotherapy (TOMO), nasopharyngeal carcinoma
