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Authors Hou Q, Guan Y, Yu W, Liu X, Wu L, Xiao M, Lü Y
Received 25 October 2018
Accepted for publication 7 January 2019
Published 15 February 2019 Volume 2019:14 Pages 367—373
DOI https://doi.org/10.2147/CIA.S192050
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Cristina Weinberg
Peer reviewer comments 2
Editor who approved publication: Dr Zhi-Ying Wu
Purpose: The aim
of this study was to investigate the relationship between obesity and cognitive
impairment in the Chinese elderly.
Patients and methods: Patients
aged 60 years or above were enrolled from the Department of Geriatrics of The
First Affiliated Hospital of Chongqing Medical University from March 2013 to
May 2017. Mini-Mental State Examination scale was used to assess the cognitive
function. Body mass index (BMI) and waist–hip ratio were used to classify
obesity. Student’s t -test, Mann–Whitney U -test, or
chi-squared test was used to compare the data between participants with normal
cognition and participants with cognitive impairment as appropriate. Univariate
logistic regression models and multivariate logistic regression models were
performed to explore the relationship between BMI or abdominal obesity and
cognitive impairment.
Results: A total
of 1,100 patients including 568 men and 532 women aged 60–98 years (median age
79 years) were enrolled. After adjusting for age, gender, smoking, drinking,
education level, hypercholesterolemia, hypertension, and diabetes, overweight
was significantly associated with a decreased risk of cognitive impairment
(OR=0.458, 95% CI=0.298–0.703, P <0.001). After adjustment for age, education
level, hypercholesterolemia, hypertension, and diabetes, abdominal obesity
remained significantly associated with an increased risk of cognitive
impairment (OR=1.532, 95% CI=1.037–2.263, P =0.032).
Conclusion: Overweight
is associated with a decreased risk of cognitive impairment in the Chinese
elderly, while abdominal obesity is associated with an increased risk of
cognitive impairment independent of conventional sociodemographic, lifestyle,
and health-related comorbid factors.
Keywords: body mass
index, cognitive function, elderly, waist-hip ratio