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以糖代谢为主的代谢重编程对胃癌生物学特性的影响
Authors Liu Y, Zhang Z, Wang J, Chen C, Tang X, Zhu J, Liu J
Received 4 October 2018
Accepted for publication 11 January 2019
Published 13 February 2019 Volume 2019:12 Pages 1195—1204
DOI https://doi.org/10.2147/OTT.S189687
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Amy Norman
Peer reviewer comments 2
Editor who approved publication: Dr Carlos E Vigil
摘要：肿瘤的瓦伯格效应体现为在氧气充足条件下通过高水平的糖摄取、糖酵解、乳酸生成来产生能量而非磷酸化。这一现象与胃癌的发生、增殖、侵袭转移、耐药、不良预后密切相关。目前的研究表明胃癌的瓦伯格效应不仅受糖酵解通路的影响，线粒体、非编码 RNA、和其他蛋白也会间接参与到这一过程中。这导致瓦伯格效应不仅会影响糖代谢，对细胞的线粒体功能、细胞凋亡、细胞周期、氨基酸代谢与脂质代谢等生物学进程也会产生影响。在本文中，我们基于糖代谢重编程，探讨了在胃癌中糖、脂质、氨基酸代谢之间的联系，阐明了线粒体在其中的作用，并总结了当前糖代谢抑制剂的发展。
Keywords: gastric
cancer, glycolysis, mitochondria, metabolic reprogramming, Helicobacter pylori
