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基于纳米氟磷灰石聚合物复合材料用于生物活性整形外科植入体和假体的发展

 

Authors Hu G, Wang H, Yao X, Bi D, Zhu G, Tang S, Wei J, Yang L, Tong P, Xiao L

Published Date August 2014 Volume 2014:9(1) Pages 3875—3884

DOI http://dx.doi.org/10.2147/IJN.S65682

Received 7 April 2014, Accepted 8 May 2014, Published 11 August 2014

Abstract: Fluorapatite with low solubility is a promising biomaterial due to its structure, which is similar to hydroxyapatite. In this study a bioactive composite of nanofluorapatite (n-FA) and polyamide 12 (PA12) was fabricated. The results revealed that the mechanical properties (such as compressive strength and elastic modulus), hydrophilicity, and antibacterial properties of n-FA/PA12 composite were obviously improved by adding n-FA into PA12 as compared with PA12. In addition, cell proliferation of MC3T3-E1 cells cultured on n-FA/PA12 composite was significantly higher than with PA12, and alkaline phosphatase activity of MC3T3-E1 cells on the n-FA/PA12 composite was expressed at obviously higher levels as compared with PA12. The results suggest that n-FA/PA12 composite could support cell proliferation and differentiation, showing good cytocompatibility. Histological evaluation indicates that n-FA/PA12 composite enhances the efficiency of new bone formation with the introduction of n-FA into PA12, and the quantity of the newly formed bone for n-FA/PA12 composite is significantly higher than with PA12. In conclusion, n-FA/PA12 composite exhibits good biocompatibility and osteogenesis, which might be used for various orthopedic prostheses and dental implants.
Keywords: nanofluorapatite, bioactive composites, cell behavior, orthopedic implants






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