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已发表论文
循环 VEGF 被用作卵巢癌诊断的生物标志物：系统回顾和汇总分析
Authors Liang B, He Q, Zhong L, Wang S, Pan Z, Wang T, Zhao Y
Published Date May 2015 Volume 2015:8 Pages 1075—1082
DOI http://dx.doi.org/10.2147/OTT.S83616
Received 27 February 2015, Accepted 31 March 2015, Published 15 May 2015
Abstract: VEGF is a frequently studied angiogenic factor in ovarian cancer (OC),
and is considered to have an important role in the progression of OC. However,
its diagnostic value has not been widely accepted because the conclusions are
inconsistent and even conflicting. Therefore, we performed a meta-analysis to
evaluate the diagnostic value of VEGF in OC. A systematic literature search was
conducted using the PubMed, Cochrane Library, EMBASE, Chinese National Knowledge
Infrastructure, and WANFANG databases for relevant published articles (the last
search update was November 18, 2014). The diagnosis sensitivity, specificity,
positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio,
and the summary receiver operating characteristic curves were pooled by Meta
DiSc 1.4 software. A total of ten studies with 1,131 subjects were finally
included in this meta-analysis. The pooled sensitivity, specificity, positive
likelihood ratio, negative likelihood ratio, diagnostic odds ratio, and summary
receiver operating characteristic curves were 0.67 (0.63–0.73), 0.78
(0.75–0.81), 3.08 (6.36–12.22), 0.39 (0.29–0.51), 9.10 (5.43–45.25), and
0.8175, respectively. Furthermore, to explore the sources of heterogeneity, we
conducted subgroup analyses based on ethnicity and sample size. The diagnostic
accuracy of VEGF was higher in an Asian population than in a Caucasian
population. A similar finding was found in subgroups with the smaller sample
size (<100 subjects). In conclusion, the present meta-analysis suggests that
VEGF has moderate diagnostic accuracy for OC. Considering our limitations and
the heterogeneity among our selected studies, larger, well-designed prospective
and multicenter validation studies are needed to evaluate the diagnostic value
of serum VEGF for OC.
Keywords: gynecological tumor, diagnosis, blood, review
Keywords: gynecological tumor, diagnosis, blood, review
