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中国人群中 GSTM1 空白基因型与胃癌的风险： 一个更新的综合分析和回顾

 

Authors Zhang XL, Cui YH

Published Date April 2015 Volume 2015:8 Pages 969—975

DOI http://dx.doi.org/10.2147/OTT.S79099

Received 11 December 2014, Accepted 2 March 2015, Published 28 April 2015

Abstract: Although a number of studies have been conducted on the association between the GSTM1  null genotype and gastric cancer in People’s Republic of China, this association remains elusive and controversial. To clarify the effects of the GSTM1  null genotype on the risk of gastric cancer, an updated meta-analysis was performed in the Chinese population. Related studies were identified from PubMed, Springer Link, Ovid, Chinese Wanfang Data Knowledge Service Platform, Chinese National Knowledge Infrastructure (CNKI), and Chinese Biology Medicine (CBM) up to November 5, 2014. A total of 25 studies including 3,491 cases and 5,921 controls were included in this meta-analysis. Overall, a significant association (odds ratio [OR] =1.47, 95% CI: 1.28–1.69) was found between the null GSTM1  and gastric cancer risk when all studies in Chinese population were pooled into the meta-analysis. In subgroup analyses stratified by quality score, geographic area, and source of controls, the same results were observed. Additionally, a significant association was found both in smokers and non-smokers. This meta-analysis showed that the null GSTM1  may be a potential biomarker for gastric cancer risk in Chinese, and further studies with gene–gene and gene–environment interactions are required for definite conclusions.
Keywords: meta-analysis, GSTM1 , polymorphism, gastric cancer






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