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Authors Yang R, Wang A, Ma L, Su Z, Chen S, Wang Y, Wu S, Wang C
Received 22 May 2018
Accepted for publication 14 September 2018
Published 23 October 2018 Volume 2018:14 Pages 2081—2088
DOI https://doi.org/10.2147/TCRM.S174961
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Colin Mak
Peer reviewer comments 2
Editor who approved publication: Professor Deyun Wang
Background and
purpose: Whether higher hematocrit
levels could increase the incidence of stroke has always been full of
controversy. This study aimed to explore the association between hematocrit and
the incidence of stroke in the Chinese population.
Subjects and
methods: The Kailuan study is a
prospective longitudinal cohort study on risk factors and events of chronic
diseases. Using a multivariable Cox proportional hazards analysis, we examined
the association between baseline hematocrit values and the incidence of stroke
in the Kailuan cohort (93,299 participants).
Results: A total of 3,624 participants developed stroke during the 9-year
follow-up period. In Cox regression models adjusted for demographic information
and for clinical variables, there was a significant association between
baseline hematocrit levels and the incidence of stroke. The highest hematocrit
quartile (quartile 5: men, hematocrit >48.6%; women, hematocrit >43.2%)
was associated with a higher incidence of stroke (HR 1.17, 95% CI
1.04–1.31, P for trend =0.0016) compared
with the lowest hematocrit quartile (quartile 1: men, hematocrit <41.5%;
women, hematocrit <36.6%). In the analysis of ischemic stroke, intracerebral
hemorrhage separately, similar association was observed in ischemic stroke, but
there were no statistical differences in intracerebral hemorrhage.
Conclusion: Higher hematocrit levels are associated with a higher incidence of
stroke in the Chinese population.
Keywords: hematocrit, stroke, cohort