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已发表论文
晚期非小细胞肺癌 (NSCLC) 患者的血浆 D-二聚体的预测值
Authors Wang Y, Wang Z
Published Date April 2015 Volume 2015:8 Pages 805—808
DOI http://dx.doi.org/10.2147/OTT.S78154
Received 26 November 2014, Accepted 17 February 2015, Published 13 April 2015
Purpose: The relationship between plasma D-dimer level and the prognosis of
advanced non-small-cell lung cancer (NSCLC) is not well studied. This study
investigated the role of plasma D-dimer as a prognostic factor in advanced
NSCLC.
Methods: The plasma D-dimer was measured in 1,931 newly diagnosed advanced NSCLC patients by enzyme-linked immunosorbent assay. Correlations between plasma D-dimer levels and other clinical parameters were analyzed. Survival curves were plotted using the Kaplan–Meier method. The Cox proportional hazard model was used for multivariate analysis.
Results: Plasma D-dimer concentrations were within the normal range in 1,393 patients (72.1%) and elevated in 538 patients (27.9%). The median overall survival was 11.5 and 8.8 months in the normal and high plasma D-dimer group, respectively (P <0.001). The progression-free survival of first-line chemotherapy was 5.0 months and 4.4 months in the groups with normal and high levels of plasma D-dimer, respectively, (P <0.001). By multivariate analyses, the elevated plasma D-dimer level was found to be an independent prognostic factor for poor survival (hazard ratio =1.245; P <0.001).
Conclusion: Plasma D-dimer is an independent determinant of poor prognosis in advanced NSCLC.
Keywords: plasma D-dimer, prognosis, non-small-cell lung cancer, performance status
Methods: The plasma D-dimer was measured in 1,931 newly diagnosed advanced NSCLC patients by enzyme-linked immunosorbent assay. Correlations between plasma D-dimer levels and other clinical parameters were analyzed. Survival curves were plotted using the Kaplan–Meier method. The Cox proportional hazard model was used for multivariate analysis.
Results: Plasma D-dimer concentrations were within the normal range in 1,393 patients (72.1%) and elevated in 538 patients (27.9%). The median overall survival was 11.5 and 8.8 months in the normal and high plasma D-dimer group, respectively (P <0.001). The progression-free survival of first-line chemotherapy was 5.0 months and 4.4 months in the groups with normal and high levels of plasma D-dimer, respectively, (P <0.001). By multivariate analyses, the elevated plasma D-dimer level was found to be an independent prognostic factor for poor survival (hazard ratio =1.245; P <0.001).
Conclusion: Plasma D-dimer is an independent determinant of poor prognosis in advanced NSCLC.
Keywords: plasma D-dimer, prognosis, non-small-cell lung cancer, performance status
