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炎症细胞在 COPD 气道重塑中的作用
Authors Wang Y, Xu J, Meng Y, Adcock IM, Yao X
Received 2 June 2018
Accepted for publication 20 July 2018
Published 12 October 2018 Volume 2018:13 Pages 3341—3348
DOI https://doi.org/10.2147/COPD.S176122
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Justinn Cochran
Peer reviewer comments 2
Editor who approved publication: Professor Chunxue Bai
摘要：慢性阻塞性肺疾病（Chronic obstructive pulmonary disease ，COPD）的基本特征是慢性支气管炎、慢性气道阻塞和肺气肿，导致肺功能逐渐发生不可逆下降。慢性炎症是 COPD 病理进程的关键环节。COPD 病理过程中的慢性炎症细胞主要包括中性粒细胞、巨噬细胞、淋巴细胞和其他炎性细胞。气道结构细胞在其中也起着重要作用。气道重塑包括组织和细胞结构性变化，包括气道壁增厚、上皮化生、杯状细胞肥大和平滑肌增生等。持续气道炎症可能参与气道重塑和小气道阻塞。然而，其潜在机制尚不清楚。在这篇综述中，我们将提供关于主要炎症细胞在慢性阻塞性肺疾病气道重塑的作用的最近观点和研究。
关键词：慢性阻塞性肺疾病；气道炎症；气道重塑
