已发表论文

纯型和混合型乳腺导管癌的临床病理特征及临床效果:一个单机构队列研究

 

Authors Zhang WW, Wu SG, Ling YH, Sun JY, Long ZQ, Hua X, Dong Y, Li FY, He ZY, Lin HX

Received 13 June 2018

Accepted for publication 4 September 2018

Published 11 October 2018 Volume 2018:10 Pages 4509—4515

DOI https://doi.org/10.2147/CMAR.S177046

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Andrew Yee

Peer reviewer comments 3

Editor who approved publication: Dr Antonella D'Anneo

Introduction: We aimed to evaluate the clinicopathologic characteristics and clinical outcomes of the mixed type versus the pure type of tubular carcinoma (TC) of the breast in a retrospective cohort study.
Materials and methods: Patients were categorized into the following three groups: patients with pure TC of the breast (the PTC group), patients with TC and carcinoma in situ of the breast (the TC-CIS group), and patients with TC and other invasive carcinomas of the breast (the TC-IC group). We compared the clinicopathologic characteristics and treatment outcomes of the three groups. The primary end point of this study was breast cancer-specific survival (BCSS). Secondary end points included distant metastasis-free survival (DMFS) and locoregional recurrence (LRR).
Results: A total of 68 patients were included in this study, including 31 patients in the PTC group, 12 in the TC-CIS group, and 25 in the TC-IC group. Our data showed that PTC and TC-CIS were more likely to be smaller in size (=0.014) and had substantially less nodal involvement (=0.019), compared with TC-IC. The median follow-up time was 64.3 months (range, 3.78–223.2 months) for all patients. No locoregional relapse was observed in any group during the follow-up period. The 10-year BCSS of the PTC, TC-CIS, and TC-IC groups was 100%, 100%, and 95.2%, respectively, and the 10-year DMFS was 92.3%, 100%, and 96.0%, respectively. There was no significant difference in terms of BCSS (=0.53) or DMFS (=0.84) between the three groups.
Conclusion: This study indicates that both the pure type and mixed type of TC of the breast show very low LRR and distant metastasis rate and have excellent survival. The TC-IC group is likely to show good prognosis similar to the PTC group. Further clinical trials with larger sample sizes as well as molecular and genetic studies are warranted.
Keywords: pure type of tubular carcinoma, mixed type of tubular carcinoma, clinicopathologic characteristics, clinical outcomes




Figure 1 BCSS (A) and DMFS (B) of the PTC group (N=31), the TC-CIS group (N=12), and the TC-IC group (N=25).