已发表论文

神经导航的高剂量重复经颅磁刺激治疗有自杀意念的抑郁症青少年: 一组连续的病例

 

Authors Pan F, Li D, Wang X, Lu S, Xu Y, Huang M

Received 2 June 2018

Accepted for publication 10 September 2018

Published 10 October 2018 Volume 2018:14 Pages 2675—2679

DOI https://doi.org/10.2147/NDT.S176125

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Amy Norman

Peer reviewer comments 6

Editor who approved publication: Dr Yu-Ping Ning

Background: A high proportion of adolescents with major depressive disorder currently do not respond to conventional treatment. Repetitive transcranial magnetic stimulation (rTMS) is a promising treatment for major depressive disorder.
Case: We report on 3 cases of adolescents with suicidal ideation receiving 7 daily 10 Hz left prefrontal rTMS combined with pharmacotherapy treatment over 1 week for major depressive episode. The left dorsolateral prefrontal cortex was identified using magnetic resonance imaging-guided neuronavigation prior to stimulation. The suicidal ideation of these patients lessened significantly following rTMS treatment. Regarding adverse effects, symptoms of hypomania occurred in two patients since day 4, but no other side effects were found.
Conclusion: Neuronavigation-guided high-dose rTMS may be an effective and feasible treatment option for depressive adolescents with suicidal ideation. Caution over treatment-emergent mania/hypomania associated with rTMS is required.
Keywords: neuronavigation, repetitive transcranial magnetic stimulation, depressive adolescents, suicidal ideation




Figure 1 The left dorsolateral prefrontal cortex (-44,40,29) was targeted using a MRI-guided...