已发表论文

年轻人的乳头状甲状腺癌患者淋巴结阳性风险较高:一项以 SEER  数据为基础的研究

 

Authors Wang J, Liu J, Pan H, Jiang C, Liu S, Zhu Z, Fang J, Zheng X, Hong S, Wang S

Received 9 March 2018

Accepted for publication 30 May 2018

Published 25 September 2018 Volume 2018:10 Pages 3867—3873

DOI https://doi.org/10.2147/CMAR.S167774

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 3

Editor who approved publication: Dr Luzhe Sun

Introduction: Currently in papillary thyroid cancer (PTC), the correlation between lymph node positivity (LN+) and patient’s age at diagnosis is still inconclusive. The aim of this study was to investigate whether younger PTC patients had higher LN+ rates.
Patients and methods: From the 1998–2013 Surveillance, Epidemiology, and End Results database, we analyzed PTC patients with at least 1 LN examined. The patients were divided into 5 groups by age separately for each T stage: ≤30; 31–40; 41–50; 51–60; >60 years.
Results: A total of 46,077 PTC patients were identified, including 8,386 (18.2%) patients aged ≤30 years, 10,971 (23.8%) patients aged 31–40 years, 11,646 (25.3%) patients aged 41–50 years, 8,596 (18.7%) patients aged 51–60 years, and 6,478 (14.1%) patients aged >60 years. In each T stage, LN+ rates were inversely associated with age at diagnosis, which was validated by multivariate logistic regression analysis (<0.001). In addition, the subset of patients 30 or younger had the highest lymph node ratio compared with other subsets (<0.001).
Conclusion: We identified that younger PTC patients have an increased predisposition for LN+ regardless of T stage. This finding could help surgeons to select the optimal treatment for younger PTC patients.
Keywords: papillary thyroid cancer, age at diagnosis, lymph node positivity, lymph node ratio, recurrence, Surveillance, Epidemiology, and End results




Figure 1 LN+ and age at diagnosis by T stage.