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Authors Lin SY, Zhang SZ, An JX, Qian XY, Gao XY, Wang Y, Zhao WX, Eastwood D, Cope DK, Williams JP
Received 21 January 2018
Accepted for publication 2 June 2018
Published 4 October 2018 Volume 2018:11 Pages 2179—2188
DOI https://doi.org/10.2147/JPR.S163340
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Minal Joshi
Peer reviewer comments 3
Editor who approved publication: Dr Katherine Hanlon
Objective: This study was to evaluate the effectiveness of ultrasound-guided
percutaneous ozone injections around the cervical dorsal root ganglions of
zoster-associated pain (ZAP) patients.
Study design: Retrospective comparative study.
Settings: The study was conducted at a pain center of a university hospital.
Patients and
methods: From June 2016 to July 2017, a total
number of 30 patients with ZAP were treated with ultrasound-guided percutaneous
ozone injection around the cervical dorsal root ganglion (DRG) at the injured
nerve level (C2-C8). A volume of 3 mL ozone-oxygen mixture at a concentration
of 30 µg/mL was injected into the area around the DRG. Patients were divided
into two groups according to their disease duration: group A (at or <3
months) and group B (>3 months). The pain severity was assessed according to
a visual analog scale, and imaging changes were evaluated by ultrasound.
Patient improvements in pain and neurologic function were evaluated during a
follow-up period from 1 to 3 months.
Results: The data showed that ozone injections reduced pain in patients
with ZAP. However, the success rate of group A was higher than group B. After
the injection, the von Frey data demonstrated decreases in both groups,
but, there were no significant differences between the groups. Moreover,
univariate logistic regression analysis and multivariate regression analysis
showed a history of diabetes mellitus had a significant effect on the treatment
results.
Conclusions: Percutaneous ozone injection around the DRG might be a useful method for
treatment-resistant cases of ZAP at the cervical level. Institutional Review
Board (IRB) approval number: HK2017-1130.
Keywords: herpes zoster, neuropathic pain, post-herpetic neuralgia, ozone
injection