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肿瘤组织中视网膜发育基因网络调节细胞因子信号功能
Authors Zheng X, Liu Q, Yi M, Qin S, Wu K
Received 4 June 2018
Accepted for publication 23 August 2018
Published 4 October 2018 Volume 2018:11 Pages 6479—6487
DOI https://doi.org/10.2147/OTT.S176113
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Manfred Beleut
Peer reviewer comments 2
Editor who approved publication: Dr Takuya Aoki
摘要：肿瘤微环境在决定癌细胞的生物学特征方面起重要的作用。细胞因子是肿瘤微环境的关键成分，通过自分泌和旁分泌途径产生的细胞因子在细胞癌变及肿瘤进展过程中起不同的功能。视网膜发育基因网络（RDGN）主要包括 DACH, SIX 和 EYA 基因家族，是维持哺乳动物多种器官的正常发育所必需的。RDGN 与细胞因子信号间存在交互作用，且表现为组织或细胞特异性，例如 CXCL8, IL-6, TGF-β, FGF 和 VEGF。RDGN 异常表达影响细胞因子信号的功能，与肿瘤细胞增殖、凋亡、新生血管形成和转移相关。作为一种潜在的肿瘤分子标志，联合检测 RDGN 可能有助于为肿瘤患者选择个体化治疗方案和精准判断患者的预后。
Keywords: DACH1, SIX1, EYA1, cytokine,
tumor, proliferation, metastasis
