已发表论文

酒石酸布托啡诺对阿片类药物诱导的呛咳的影响:一项基于随机对照试验的荟萃分析

 

Authors Zhang J, Miao S, Tu Q, Shi M, Zou L, Liu S, Wang G

Received 17 July 2018

Accepted for publication 27 August 2018

Published 2 October 2018 Volume 2018:12 Pages 3263—3268

DOI https://doi.org/10.2147/DDDT.S180533

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Cristina Weinberg

Peer reviewer comments 3

Editor who approved publication: Dr Anastasios Lymperopoulos

目的:通过荟萃分析评估酒石酸布托啡诺对阿片类药物引起的咳嗽的作用。
方法:检索 PubMedEmbaseCochrane 图书馆和中国知网等数据库,纳入研究酒石酸布托啡诺对阿片类药物引起的咳嗽的影响的随机对照试验。使用 RevMan 5.3 版进行数据分析。
结果:共纳入涉及 942 名患者的 项随机对照实验。结果显示,与对照组相比,酒石酸布托啡诺可以降低阿片类药物诱导的呛咳的发生率(risk ratio [RR]=0.17, 95% confidence interval [CI] [0.09-0.33], <0.00001)。亚组分析显示,酒石酸布托啡诺可以降低轻度呛咳(RR=0.30, 95% CI [0.11, 0.78], =0.01),中度呛咳(RR=0.08, 95% CI [0.03, 0.22], <0.00001),及重度呛咳(RR=0.08, 95% CI [0.02, 0.30], =0.0001)的发生率。
结论:本研究显示酒石酸布托啡诺能有效预防阿片类药物引起的咳嗽的发生,并且降低阿片咳嗽的严重程度。
关键词:酒石酸布托啡诺,阿片类药物,呛咳,随机对照试验




Figure 1 PRISMA flowchart of the included studies.