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已发表论文
针对缺氧的先进纳米材料用于增强放疗效果
Authors Li J, Shang W, Li Y, Fu S, Tian J, Lu L
Received 12 May 2018
Accepted for publication 9 August 2018
Published 1 October 2018 Volume 2018:13 Pages 5925—5936
DOI https://doi.org/10.2147/IJN.S173914
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Justinn Cochran
Peer reviewer comments 3
Editor who approved publication: Dr Lei Yang
Abstract: Hypoxia within
solid tumors is often responsible for the failure of radiotherapy. The
development of hypoxia-targeting nanomaterials – aimed at enhancing the effect
of radiotherapy by electrical or heat effects and at modulating hypoxia in the
tumor microenvironment – is a promising strategy to address this issue. We
provide an overview of recently developed advanced materials that potentiate
radiotherapy. First, we summarize novel materials for oxygen delivery or
production to modify the tumor microenvironment, thus improving the effects of
ionizing radiation. Second, we present new approaches for the design of high-Z
element–based multifunctional nanoplatforms to enhance radiotherapy. Third,
novel drug delivery systems for hypoxic regions and hypoxia-inducible
factor-1–targeted therapies are discussed. Fourth, we establish the
effectiveness of X-ray- or near-infrared–responsive nanoparticles for
selectively triggering therapeutic effects under hypoxic conditions. Finally,
this review emphasizes the importance of research in the field of nanomedicine
focused on tumor hypoxia to improve clinical outcomes.
Keywords: radiotherapy, hypoxia, nanomaterials, hypoxia-inducible factor 1
Keywords: radiotherapy, hypoxia, nanomaterials, hypoxia-inducible factor 1
