已发表论文

提高的衍生中性粒细胞与淋巴细胞比率以及乳腺成像 - 报告和数据系统分类可预测新辅助化疗治疗非远处转移性 HER2+ 乳腺癌患者的较低生存率

 

Authors Li Y, Shao Y, Bai L, Zhou X

Received 17 May 2018

Accepted for publication 16 July 2018

Published 24 September 2018 Volume 2018:10 Pages 3841—3847

DOI https://doi.org/10.2147/CMAR.S174537

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 2

Editor who approved publication: Dr Antonella D'Anneo



Introduction: The prognostic role of the derived neutrophil-to-lymphocyte ratio (dNLR) in human patients with HER2+ breast cancer is not well understood. Here, we aimed to investigate the prognostic significance of dNLR in patients with HER2+ breast cancer undergoing neoadjuvant chemotherapy.
Methods: A total of 310 patients with non-distant metastatic HER2+ breast cancer who had received neoadjuvant chemotherapy in our hospital from May 2006 to November 2013 were retrospectively included in this study. Kaplan–Meier curves were used to assess overall survival (OS) and disease-free survival (DFS). The Cox regression model was used to evaluate the prognostic value of dNLR and Breast Imaging-Reporting and Data System (BI-RADS) classification, as well as other clinicopathological parameters in patients with HER2+ breast cancer treated with neoadjuvant chemotherapy.
Results: We found that dNLR prior to treatment was positively correlated with tumor size, tumor stage, lymphovascular invasion, and histological grade (<0.05). The median OS of patients with high dNLR and low dNLR were 44.2 and 69.9, respectively (<0.001), and the median DFS of patients with high dNLR and low dNLR were 15.3 and 22.1 months, respectively (<0.001). Multivariate analysis showed that dNLR was an independent risk factor for OS (HR =1.726; 95% CI: 1.072–2.662; =0.009) and DFS (HR =1.658; 95% CI: 1.125–2.426; =0.026). Moreover, increased BI-RADS classification independently predicted short OS (HR =1.609; 95% CI: 1.216–2.351; =0.015) and DFS (HR =1.925; 95% CI: 1.526–2.635; =0.021).
Conclusion: dNLR prior to treatment and BI-RADS classification are independent prognostic factors in patients with HER2+ breast cancer receiving neoadjuvant chemotherapy.
Keywords: breast cancer, inflammation, dNLR, Breast Imaging-Reporting and Data System, prognosis




Figure 2 Disease-free survival of patients with HER2+ breast cancer stratified by dNLR.