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已发表论文
在中国汉族患有强迫症的人群中进行的 DLGAP1 rs11081062 与 EFNA5 rs26728 多态性之间的关联的研究
Authors Li J, Cui J, Wang X, Ma J, Niu H, Ma X, Zhang X, Liu S
Published Date April 2015 Volume 2015:11 Pages 897—905
DOI http://dx.doi.org/10.2147/NDT.S75009
Received 26 September 2014, Accepted 12 February 2015, Published 1 April 2015
Background: A recent genome-wide association study indicated that the single
nucleotide polymorphisms (SNPs) rs11081062 in DLGAP1 and rs26728 in EFNA5 were associated with
obsessive–compulsive disorder (OCD) in Caucasians. The present case–control
association study assessed the global relevance of these two SNPs with respect
to OCD subtypes in a Chinese Han population.
Methods: We recruited 320 OCD patients and 431 age- and sex-matched controls from a Chinese Han population. rs11081062 and rs26728 SNPs were genotyped by real-time TaqMan polymerase chain reaction, and the chi-squared test was used to compare allele and genotype frequencies of variants between the two groups.
Results: No significant differences were found in allele or genotype frequencies of DLGAP1 rs11081062 and EFNA5 rs26728 between the OCD and control groups. Moreover, consistently negative results were observed when classifying by sex, onset age, and comorbidity. However, on analyzing OCD subphenotypes, significant associations were observed between rs11081062 and the presence of contamination obsessions and cleaning compulsions (χ 2=7.724, P =0.021 by genotype; χ 2=3.745, P =0.053 by allele; and χ 2=0.821, P =0.365 by genotype, χ 2=27.809, P =0.000 by allele, respectively), and rs26728 with the presence of repeating compulsions (χ 2=8.285, P =0.004 by genotype; χ 2=7.512, P =0.006 by allele).
Conclusion: Although we found no association between DLGAP1 rs11081062 and EFNA5 rs26728 SNPs with OCD in a Chinese Han population, obvious associations were observed with OCD subphenotypes. Therefore, it appears to be useful to divide OCD into more homogeneous subphenotypes to help understand the complex genetic basis of this disorder. Further investigations are needed to replicate these findings using larger sample sizes, different populations, and other polymorphisms.
Keywords: DLGAP1, EFNA5, obsessive-compulsive disorder, polymorphism
Methods: We recruited 320 OCD patients and 431 age- and sex-matched controls from a Chinese Han population. rs11081062 and rs26728 SNPs were genotyped by real-time TaqMan polymerase chain reaction, and the chi-squared test was used to compare allele and genotype frequencies of variants between the two groups.
Results: No significant differences were found in allele or genotype frequencies of DLGAP1 rs11081062 and EFNA5 rs26728 between the OCD and control groups. Moreover, consistently negative results were observed when classifying by sex, onset age, and comorbidity. However, on analyzing OCD subphenotypes, significant associations were observed between rs11081062 and the presence of contamination obsessions and cleaning compulsions (χ 2=7.724, P =0.021 by genotype; χ 2=3.745, P =0.053 by allele; and χ 2=0.821, P =0.365 by genotype, χ 2=27.809, P =0.000 by allele, respectively), and rs26728 with the presence of repeating compulsions (χ 2=8.285, P =0.004 by genotype; χ 2=7.512, P =0.006 by allele).
Conclusion: Although we found no association between DLGAP1 rs11081062 and EFNA5 rs26728 SNPs with OCD in a Chinese Han population, obvious associations were observed with OCD subphenotypes. Therefore, it appears to be useful to divide OCD into more homogeneous subphenotypes to help understand the complex genetic basis of this disorder. Further investigations are needed to replicate these findings using larger sample sizes, different populations, and other polymorphisms.
Keywords: DLGAP1, EFNA5, obsessive-compulsive disorder, polymorphism
