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水溶性 L-半胱氨酸包覆的 FePt 纳米粒子被用作神经胶质瘤的双 MRI/CT 成像的造影剂

 

Authors Liang SY, Zhou Q, Wang M, Zhu YH, Wu QZ, Yang XL

Published Date March 2015 Volume 2015:10 Pages 2325—2333

DOI http://dx.doi.org/10.2147/IJN.S75174

Received 30 September 2014, Accepted 12 January 2015, Published 23 March 2015

Abstract: Nanoparticles (NPs) are advantageous for the delivery of diagnosis agents to brain tumors. In this study, we attempted to develop an l-cysteine coated FePt (FePt-Cys) NP as MRI/CT imaging contrast agent for the diagnosis of malignant gliomas. FePt-Cys NPs were synthesized through a co-reduction route, which was characterized by transmission electron microscopy, high-resolution transmission electron microscopy, powder X-ray diffraction, Fourier transform infrared spectroscopy, and dynamic light scattering. The MRI and CT imaging ability of FePt-Cys NPs was evaluated using different gliomas cells (C6, SGH44, U251) as the model. Furthermore, the biocompatibility of the as-synthesized FePt-Cys NPs was evaluated using three different cell lines (ECV304, L929, and HEK293) as the model. The results showed that FePt-Cys NPs displayed excellent biocompatibility and good MRI/CT imaging ability, thereby indicating promising potential as a dual MRI/CT contrast agent for the diagnosis of brain malignant gliomas.
Keywords: CT, glioma, MRI






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