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临床病人定植样品中产 MCR-1 与 NDM-5 大肠埃希菌的特点及耐药分析
Authors Feng S, Shen C, Chen H, Zheng X, Xia Y, Zhong LL, Huang X, Wu X, Tian GB
Received 15 April 2018
Accepted for publication 3 June 2018
Published 14 August 2018 Volume 2018:11 Pages 1157—1161
DOI https://doi.org/10.2147/IDR.S171164
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Amy Norman
Peer reviewer comments 2
Editor who approved publication: Dr Eric Nulens
摘要：多粘菌素 E 为临床治疗碳青霉烯类耐药肠杆菌科的最后一道防线。近年来，可移动的多粘菌素耐药基因 mcr-1 在肠杆菌科中的检出率呈现上升趋势。值得注意的是，当 mcr-1 基因传播至产碳青霉烯酶的肠杆菌科中，能够导致高耐药性菌株的出现，甚至无药可治。目前已有研究报道在动物及患有感染性疾病的病人中发现了携带 mcr-1 及碳青霉烯类耐药基因的菌株。我们的研究报道了一株携带有 mcr-1 及 bla NDM-5 基因的大肠埃希菌，两种耐药基因分别位于 IncX4 及 IncX3 型质粒上，且具有共同转移的能力，能够导致抗生素治疗的失败。
Keywords: Escherichia coli , MCR-1, NDM-5, co-production
