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已发表论文
ERCC1 rs11615 基因多态性与以奥沙利铂为基础的胃肠道癌症化疗临床结果之间的关联： 一项综合分析
Authors Ma SC, Zhao Y, Zhang T, Ling XL, Zhao D
Published Date March 2015 Volume 2015:8 Pages 641—648
DOI http://dx.doi.org/10.2147/OTT.S80913
Received 14 January 2015, Accepted 11 February 2015, Published 16 March 2015
Purpose: The relationship between the excision repair cross-complementing 1 (ERCC1 ) rs11615 polymorphism (C/T) and responses to oxaliplatin-based chemotherapy for gastric cancer (GC) and colorectal cancer (CRC) patients is controversial. Therefore, we performed a meta-analysis to assess this relationship.
Method: Relevant studies were retrieved by searching the PubMed database. A systematic review and meta-analysis was performed to evaluate the predictive value of the ERCC1 rs11615 polymorphism for the clinical outcomes of GC and CRC patients receiving oxaliplatin-based chemotherapy. Therapeutic response to chemotherapy, progression-free survival (PFS), and overall survival (OS) were analyzed.
Results: A total of 22 studies were included in this meta-analysis, including 1,242 cases of GC and 1,772 cases of CRC. For the ERCC1 rs11615 polymorphism, the T allele was associated with a reduced response to chemotherapy in Asians and GC patients (P <0.05). On the other hand, the T allele was associated with a significant increase in the risk for shorter PFS and OS in all patients (PFS: hazard ratio [HR] =1.22, P <0.001, 95% confidence interval [CI] =0.93–1.51 and OS: HR =1.12, P <0.001, 95% CI =0.85–1.40).
Conclusion: The ERCC1 rs11615 polymorphism was closely associated with the clinical outcomes of GC and CRC patients treated with oxaliplatin-based chemotherapy.
Keywords: ERCC1 rs11615, polymorphism, oxaliplatin-based chemotherapy, gastric cancer, colorectal cancer, meta-analysis
Method: Relevant studies were retrieved by searching the PubMed database. A systematic review and meta-analysis was performed to evaluate the predictive value of the ERCC1 rs11615 polymorphism for the clinical outcomes of GC and CRC patients receiving oxaliplatin-based chemotherapy. Therapeutic response to chemotherapy, progression-free survival (PFS), and overall survival (OS) were analyzed.
Results: A total of 22 studies were included in this meta-analysis, including 1,242 cases of GC and 1,772 cases of CRC. For the ERCC1 rs11615 polymorphism, the T allele was associated with a reduced response to chemotherapy in Asians and GC patients (P <0.05). On the other hand, the T allele was associated with a significant increase in the risk for shorter PFS and OS in all patients (PFS: hazard ratio [HR] =1.22, P <0.001, 95% confidence interval [CI] =0.93–1.51 and OS: HR =1.12, P <0.001, 95% CI =0.85–1.40).
Conclusion: The ERCC1 rs11615 polymorphism was closely associated with the clinical outcomes of GC and CRC patients treated with oxaliplatin-based chemotherapy.
Keywords: ERCC1 rs11615, polymorphism, oxaliplatin-based chemotherapy, gastric cancer, colorectal cancer, meta-analysis
