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已发表论文
含苄基的新型三唑衍生物的设计、合成及抗真菌活性
Authors Xu K, Huang L, Xu Z, Wang Y, Bai G, Wu Q, Wang X, Yu S, Jiang Y
Published Date March 2015 Volume 2015:9 Pages 1459—1467
DOI http://dx.doi.org/10.2147/DDDT.S74989
Received 26 September 2014, Accepted 18 December 2014, Published 11 March 2015
Approved for publication by Professor Shu-Feng Zhou
Abstract: In previous studies undertaken by our group, a series of 1-(1H -1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-substituted-2-propanols (1a–r), which were analogs of fluconazole, was designed and synthesized by click chemistry. In the study reported here, the in vitro antifungal activities of all the target compounds were evaluated against eight human pathogenic fungi. Compounds 1a, 1q, and 1r showed the more antifungal activity than the others.
Keywords: triazole, synthesis, antifungal activity, CYP51
Keywords: triazole, synthesis, antifungal activity, CYP51
