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已发表论文
微小 RNAs、长非编码 RNAs 和环状 RNA：潜在的肿瘤生物标志物和结直肠癌治疗的目标
Authors Yang S, Sun Z, Zhou Q, Wang W, Wang G, Song J, Li Z, Zhang Z, Chang Y, Xia K, Liu J, Yuan W
Received 23 February 2018
Accepted for publication 11 April 2018
Published 26 July 2018 Volume 2018:10 Pages 2249—2257
DOI https://doi.org/10.2147/CMAR.S166308
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Jaya Mallela
Peer reviewer comments 3
Editor who approved publication: Professor Nakshatri
Abstract: Noncoding RNAs
(ncRNAs) can be divided into microRNAs (miRNAs), long noncoding RNAs (lncRNAs),
circular RNAs (circRNAs), pRNAs, and tRNAs. Traditionally, miRNAs exert their
biological function mainly through the inhibition of translation via the
induction of target RNA transcript degradation. lncRNAs and circRNAs were once
considered to have no potential to code proteins. Here, we will review the
current knowledge on ncRNAs in relation to their origins, characteristics, and
functions. We will also review how ncRNAs work as competitive endogenous RNA,
gene transcription and expression regulators, and RNA-binding protein sponges
in colorectal cancer (CRC). Notably, except for the abovementioned mechanisms,
recent advances revealed that lncRNAs can also act as the precursor of miRNAs,
and a small portion of lncRNAs and circRNAs was verified to have the potential
to code proteins, providing new evidence for the significance of ncRNAs in CRC
tumorigenesis and development.
Keywords: biomarker, competitive endogenous RNA, tumorigenesis, epithelial-to-mesenchymal transition, invasion, metastasis, chemoresistance
Keywords: biomarker, competitive endogenous RNA, tumorigenesis, epithelial-to-mesenchymal transition, invasion, metastasis, chemoresistance
