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已发表论文
miR-19b 可用作乳腺癌的预后生物标志物并通过 PI3K/AKT 信号传导途径促进肿瘤进展
Authors Li C, Zhang J, Ma Z, Zhang F, Yu W
Received 13 April 2018
Accepted for publication 26 May 2018
Published 16 July 2018 Volume 2018:11 Pages 4087—4095
DOI https://doi.org/10.2147/OTT.S171043
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Amy Norman
Peer reviewer comments 3
Editor who approved publication: Dr Samir Farghaly
Background: MicroRNAs
(miRNAs) are involved in tumor progression of various human malignancies.
MicroRNA-19b (miR-19b) has been described as serving a crucial role in
tumorigenesis of breast cancer. The purpose of this study was to investigate
the expression patterns, clinical value, and functional role of miR-19b in
breast cancer.
Methods: Expression of miR-19b was estimated by quantitative real time PCR. Kaplan–Meier survival analysis and Cox regression assay were performed to explore the prognostic value of miR-19b. The functional role of miR-19b was verified using cell experiments.
Results: Upregulated miR-19b expression was observed in breast cancer tissues and cells compared with the controls (all P <0.05). The miR-19b expression was associated with distant metastasis and TNM stage. The survival curves showed that high miR-19b was correlated with poor overall survival of the patients (log-rank P =0.002). Furthermore, miR-19b was proven to be an independent prognostic factor for patients. By using miR-19b mimic and inhibitor, cell proliferation, migration, and invasion were enhanced by miR-19b overexpression but were suppressed by reduction of miR-19b (all P <0.05). Besides, PI3K/AKT was demonstrated to be activated by miR-19b in breast cancer cells.
Conclusion: The overexpression of miR-19b serves as a candidate prognostic biomarker of breast cancer and may be involved in the tumor progression through PI3K/AKT pathway.
Keywords: microRNA-19b, prognosis, progression, breast cancer
Methods: Expression of miR-19b was estimated by quantitative real time PCR. Kaplan–Meier survival analysis and Cox regression assay were performed to explore the prognostic value of miR-19b. The functional role of miR-19b was verified using cell experiments.
Results: Upregulated miR-19b expression was observed in breast cancer tissues and cells compared with the controls (all P <0.05). The miR-19b expression was associated with distant metastasis and TNM stage. The survival curves showed that high miR-19b was correlated with poor overall survival of the patients (log-rank P =0.002). Furthermore, miR-19b was proven to be an independent prognostic factor for patients. By using miR-19b mimic and inhibitor, cell proliferation, migration, and invasion were enhanced by miR-19b overexpression but were suppressed by reduction of miR-19b (all P <0.05). Besides, PI3K/AKT was demonstrated to be activated by miR-19b in breast cancer cells.
Conclusion: The overexpression of miR-19b serves as a candidate prognostic biomarker of breast cancer and may be involved in the tumor progression through PI3K/AKT pathway.
Keywords: microRNA-19b, prognosis, progression, breast cancer
