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已发表论文
用于光学/磁共振双模成像的脑胶质瘤靶向胶束
Authors Zhou Q, Mu K, Jiang L, Xie H, Liu W, Li Z, Qi H, Liang S, Xu H, Zhu Y, Zhu W, Yang X
Published Date March 2015 Volume 2015:10 Pages 1805—1818
DOI http://dx.doi.org/10.2147/IJN.S72910
Received 19 August 2014, Accepted 10 November 2014, Published 5 March 2015
Abstract: Surgical resection is the primary mode for glioma treatment, while
gross total resection is difficult to achieve, due to the invasiveness of the
gliomas. Meanwhile, the tumor-resection region is closely related to survival
rate and life quality. Therefore, we developed optical/magnetic resonance
imaging (MRI) bifunctional targeted micelles for glioma so as to delineate the
glioma location before and during operation. The micelles were constructed
through encapsulation of hydrophobic superparamagnetic iron oxide nanoparticles
(SPIONs) with polyethylene glycol-block -polycaprolactone
(PEG-b -PCL) by using a
solvent-evaporation method, and modified with a near-infrared fluorescent
probe, Cy5.5, in addition to the glioma-targeting ligand lactoferrin (Lf).
Being encapsulated by PEG-b -PCL, the
hydrophobic SPIONs dispersed well in phosphate-buffered saline over 4 weeks,
and the relaxivity (r 2) of
micelles was 215.4 mM–1·s–1, with sustained satisfactory
fluorescent imaging ability, which might have been due to the interval formed
by PEG-b -PCL for avoiding the fluorescence
quenching caused by SPIONs. The in vivo results indicated that the
nanoparticles with Lf accumulated efficiently in glioma cells and prolonged the
duration of hypointensity at the tumor site over 48 hours in the MR image compared
to the nontarget group. Corresponding with the MRI results, the margin of the
glioma was clearly demarcated in the fluorescence image, wherein the average
fluorescence intensity of the tumor was about fourfold higher than that of
normal brain tissue. Furthermore,
3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide assay results
showed that the micelles were biocompatible at Fe concentrations of 0–100
µg/mL. In general, these optical/MRI bifunctional micelles can specifically
target the glioma and provide guidance for surgical resection of the glioma
before and during operation.
Keywords: MRI, fluorescence image, micelles, lactoferrin, glioma
Keywords: MRI, fluorescence image, micelles, lactoferrin, glioma
