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已发表论文
在中国对 COPD 患者的测试中，COPD 评估测试与计算机断层（CT）扫描测量之间有良好的相关性
Authors Zhang Y, Tu YH, Fei GH
Published Date March 2015 Volume 2015:10(1) Pages 507—514
DOI http://dx.doi.org/10.2147/COPD.S77257
Received 9 November 2014, Accepted 10 January 2015, Published 5 March 2015
Background: The chronic obstructive pulmonary disease (COPD) assessment test (CAT)
is a validated simple instrument to assess health status, and it correlates
well with the severity of airway obstruction in COPD patients. However, little
is known about the relationships between CAT scores and quantitative computed
tomography (CT) measurements of emphysema and airway wall thickness in COPD
patients in the People’s Republic of China.
Methods: One hundred and twelve participants including 63 COPD patients and 49 normal control subjects were recruited. All participants were examined with high-resolution CT to get the measurements of emphysema (percentage of pixels below -950 HU [%LAA–950]) and airway wall thickness (wall area percentage and the ratio of airway wall thickness to total diameter). Meanwhile, they completed the CAT and modified Medical Research Council questionnaire independently.
Results: Significantly higher CAT scores and CT measurements were found in COPD patients compared with normal control subjects (P <0.05), and there was a tendency of higher CAT scores and CT measurements with increasing disease severity measured by GOLD staging system. Positive correlations were found between CAT scores and CT measurements (P <0.01). Using multiple linear stepwise regression, CAT score =-46.38+0.778× (wall area percentage) +0.203× (%LAA–950) (P <0.001). Meanwhile, CAT scores and CT measurements in COPD patients all positively correlated with the modified Medical Research Council grades and negatively correlated with FEV1% (P <0.01).
Conclusion: CAT scores correlate well with the quantitative CT measurements in COPD patients, which may provide an imaging evidence that the structural changes of the lungs in this disease are associated with the health status measured by CAT.
Keywords: chronic obstructive pulmonary disease, pulmonary function, quantitative computed tomography
Methods: One hundred and twelve participants including 63 COPD patients and 49 normal control subjects were recruited. All participants were examined with high-resolution CT to get the measurements of emphysema (percentage of pixels below -950 HU [%LAA–950]) and airway wall thickness (wall area percentage and the ratio of airway wall thickness to total diameter). Meanwhile, they completed the CAT and modified Medical Research Council questionnaire independently.
Results: Significantly higher CAT scores and CT measurements were found in COPD patients compared with normal control subjects (P <0.05), and there was a tendency of higher CAT scores and CT measurements with increasing disease severity measured by GOLD staging system. Positive correlations were found between CAT scores and CT measurements (P <0.01). Using multiple linear stepwise regression, CAT score =-46.38+0.778× (wall area percentage) +0.203× (%LAA–950) (P <0.001). Meanwhile, CAT scores and CT measurements in COPD patients all positively correlated with the modified Medical Research Council grades and negatively correlated with FEV1% (P <0.01).
Conclusion: CAT scores correlate well with the quantitative CT measurements in COPD patients, which may provide an imaging evidence that the structural changes of the lungs in this disease are associated with the health status measured by CAT.
Keywords: chronic obstructive pulmonary disease, pulmonary function, quantitative computed tomography
