已发表论文

TCF21 在肿瘤发展中的多种生物学功能

 

Authors Jiang X, Yang Z

Received 29 January 2018

Accepted for publication 26 April 2018

Published 19 June 2018 Volume 2018:11 Pages 3533—3539

DOI https://doi.org/10.2147/OTT.S164033

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Justinn Cochran

Peer reviewer comments 2

Editor who approved publication: Dr William Cho

摘要:转录因子 21TCF21)是一种碱性螺旋--螺旋转录因子,其与 DNA 结合并在发育过程中通过间充质-上皮转化调节细胞生长和分化。TCF21  基因在多种人类癌症中表观遗传学失活,并发挥广泛作用,包括调节上皮-间质转化,侵袭,转移,细胞周期和自噬。本综述着重于 TCF21 在肿瘤发展中作用的研究进展。我们系统地阐述了 TCF21 在各种癌症中的生物学功能,揭示了其多种生物学作用的分子基础,并为今后的研究提供了新的方向。
Keywords: TCF21, cancer, DNA methylation, EMT, invasion, metastasis, cell cycle




Figure 2 TCF21 regulates different functions by interacting with different partners.