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Authors Kong W, Cheng Y, Liang H, Chen Q, Xiao C, Li K, Huang Z, Zhang J
Received 30 August 2017
Accepted for publication 19 March 2018
Published 19 June 2018 Volume 2018:11 Pages 3541—3549
DOI https://doi.org/10.2147/OTT.S150340
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Akshita Wason
Peer reviewer comments 2
Editor who approved publication: Dr Samir Farghaly
Background: Studies have shown that
miR-17-5p plays an important role in the development of cancer. The aim of this
meta-analysis was to quantitatively analyze the association of miR-17-5p with
prognosis in various cancers.
Materials and methods: We searched the PubMed, EMBASE, Web of Science,
and Cochrane library databases for relevant studies through August 2017. The
prognostic data and clinicopathological features of overall survival (OS) and
disease-free survival (DFS) were extracted to investigate the association
between miR-17-5p expression and tumor prognosis. In addition, odds ratios
(ORs) were used to assess the correlations between miR-17-5p expression and
clinicopathological characteristics.
Results: A total of ten studies were incorporated into
this systematic review, and we found that high miR-17-5p expression can predict
poor OS for malignancies (combined hazard ratio [HR]=1.87; 95% confidence
interval [CI], 1.37–2.55; P =0.000) as well as
poor DFS (combined HR=1.60; 95% CI, 1.05–2.44; P =0.027).
Further subgroup analyses suggested that high miR-17-5p expression was related
to poor OS in Asian patients (combined HR=1.92; 95% CI, 1.37–2.71; P =0.000) and the serum/plasma
sample source subgroup (combined HR=2.13; 95% CI, 1.36–3.31; P =0.001). The combined OR
indicated that the expression of miR-17-5p was associated with lymph node
invasion (OR=1.28; 95% CI, 1.05–1.56; P =0.016) and venous
invasion (OR=1.92; 95% CI, 1.40–2.63; P =0.000).
Conclusion: Elevated expression of miR-17-5p suggested a
poor prognosis in cancer patients and may serve as a new tumor marker to
monitor cancer development and progression.
Keywords: miR-17-5p,
cancer, prognosis, meta-analysis